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'We listen with an open ear and a closed mouth ~ Therefore we do not judge, criticise or condemn'
Posted by: Little White Dove on Friday, May 02, 2008 - 02:05 PM
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UPPSALA, Sweden, -- Swedish scientists have developed a new method of filming and also directing blood vessel cells so they move in accordance with targeted signals. Researchers at Uppsala University said the method can also be used to study how migration of cancer cells and nerves can be controlled. "Our study shows that a simple gradient from a signal protein is sufficient to tell the blood vessel cell in which direction it is to move. We have also been able to show that the form of the gradient governs the way in which the cell moves," said Irmeli Barkefors, a postgraduate student at Uppsala University. The researchers are now developing the method further in order to study targeted migration in complicated organ culture systems, whereby interaction between different cell types can be studied. "The method can basically be adapted to facilitate study of all types of cells. It is particularly important to study the mechanisms that determine whether or not cancer cells spread," said Johan Kreuger, who has been heading the project. The findings are to appear in the Journal of Biological Chemistry.
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Posted by: Little White Dove on Thursday, May 01, 2008 - 02:05 PM
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HOUSTON, -- U.S. scientists said they have discovered a receptor's role as a cause of certain eye diseases, including glaucoma. The researchers at the Texas A&M University's Institute of Biosciences and Technology said their finding might lead to development of new eye disease treatments. "Gprotein coupled receptors (GPCRs) regulate a variety of physiological functions, from vision, olfaction, taste and reproductive biology to cardiovascular functions," said Professor Mingyao Liu, senior author of the study. "GPCRs are the largest membrane receptor family in the human genome. Our study focuses on Gpr48, a new hormone receptor in animals and humans." The scientists found Gpr48 plays an important role in anterior segment development and is also key in various physiological functions throughout the body. Deletion of the Gpr48 receptor in mice resulted in various forms of anterior segment dysgenesis, including microphthalmia (small eyes), iris hypoplasia (underdeveloped iris), iridiocorneal angle malformation (irregular angle of the iris and cornea), cornea dysgenesis (clouding of the cornea) and cataracts. Future research could validate Gpr48 as a potential therapeutic target, Liu said. The research is to appear in a future issue of the Proceedings of the National Academy of Sciences and is currently available at the journal's Web site.
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Posted by: Little White Dove on Thursday, May 01, 2008 - 11:45 AM
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BETHESDA, Md., -- U.S. government researchers said they have started the first comprehensive database of the microbes that inhabit human mouths. The scientists from the National Institute of Dental and Craniofacial Research -- part of the National Institutes of Health -- are compiling the first comprehensive database of the approximately 600 distinct micro-organisms known to live in the mouth. The researchers
said their free online compendium called the Human Oral Microbiome Database provides detailed biological entries for each species and an extensive catalog of the thousands of genes that the microbes express. "The HOMD fills a critical research need," said NIDCR director Dr. Lawrence Tabak. "The oral microbiome is extremely rich in data, and HOMD becomes the essential search engine for scientists to view and retrieve this information, generate novel hypotheses, make comp-
utational discoveries and ultimately develop more biologically sound therapies to control oral diseases." The site, managed by scientists at the Forsyth Institute in Boston and King's College London in Britain is located at http://www.homd.org.
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Posted by: Little White Dove on Thursday, April 24, 2008 - 02:05 PM
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EVANSTON, Ill., -- U.S. scientists have reversed gene therapy procedures to develop an experimental technique for preventing and treating disease linked with genetic defects. In gene therapy, a working gene is inserted into a cell to replace a faulty or absent gene. But now a team led by Northwestern University Assistant Professor of physics Adilson Motter has developed a counterintuitive approach -- the targeted removal of genes to restore function in cells with genetic defects, such as mutations. The study grew from Motter's work on the U.S. power grid -- a complex system that has many similarities with biological systems. After the largest power outage in U.S. history occurred in 2003, experts determined the event could have been reduced or avoided by instigating small intentional blackouts in the system during the initial hours of instability. "And the same could be valid in biology, where a defective gene may trigger a cascade of 'failures' along the cellular network," said Motter. "Our recent research shows that what's true in power networks is also true in biological networks. Inflicting a small amount of damage can control what otherwise would be much more significant damage." The study appears online in the journal Molecular Systems Biology.
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Posted by: Little White Dove on Wednesday, April 23, 2008 - 02:05 PM
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PROVIDENCE, R.I. -- A study has identified which U.S. women are most likely to use a microbicide to prevent sexual transmission of the human immunodeficiency virus. Researchers at Miriam Hospital and Brown University in Providence, R.I., found women who have used protective methods in the past, and those with casual sexual partners, were more willing to use a microbicide compared with their peers. "The results may seem to be an obvious finding but they are important because science has very little direct evidence of what characteristics and situations in women's lives would make them more likely to want to use a microbicide to prevent HIV infection," said psychologist Kathleen Morrow, the study's lead author and an assistant professor at Brown. Morrow and her team designed the "Willingness to Use Microbicides" scale. The scale consists of a series of questions about particular situations, such as, "Would you have wanted to use a microbicide the last time you had sex with your partner?" The scale also includes product-related questions, such as, "If a microbicide costs about as much as a male condom, would you have used it?" The research was detailed in the journal Healthy Psychology.
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Posted by: Little White Dove on Tuesday, April 22, 2008 - 02:05 PM
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LOS ANGELES, -- A U.S.-led international study has described for the first time the mechanisms by which variants of the gene CAPON can disrupt normal heart rhythm. The researchers from the Cedars-Sinai Heart Institute, Johns Hopkins University and the China Medical University and Hospital in Taiwan said CAPON, until recently, wasn't suspected of existing in heart tissue or playing a role in heart function. The study, conducted in guinea pigs, not only confirmed CAPON naturally exists in the heart's ventricles but also showed CAPON interacts with a signaling molecule in heart muscle to influence signaling pathways and modify cell-to-cell interactions that control the heart's electrical currents. The research, led by Dr. Eduardo Marban, director of the Cedars-Sinai Heart Institute, appeared in a issue of the Proceedings of the National Academy of Sciences.
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Posted by: Little White Dove on Monday, April 21, 2008 - 02:05 PM
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PHILADELPHIA, -- U.S. biologists studying the genomes of viruses infecting the bacteria E. coli, P. aeruginosa and L. lactis found many of them exhibit codon bias. The researchers at the University of Pennsylvania and Harvard University said codon bias is the tendency to preferentially encode a protein with a particular spelling. They analyzed patterns of codon usage across 74 bacteriophages and their findings extend the translational theory of codon bias to the viral kingdom, demonstrating the viral genome is selected to obey the preferences of its host. "The host bacterium is exerting a strong evolutionary pressure on the virus," said Joshua Plotkin, lead author and an assistant professor at Penn. "This happens because a virus must hijack the machinery of its host in order to reproduce. We are seeing that viruses are forced to adopt the particular codon choices preferred by the bacterium they infect. "Like a bee and a flower, an example of co-evolution between two large organisms, the same fundamental biological processes operate between two small organisms, as reflected in their genome sequences," Plotkin added. The study that included Grzegorz Kudla at Penn and Julius Lucks and David Nelson at Harvard appeared in the journal PLoS Computational Biology.
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Posted by: Little White Dove on Sunday, April 20, 2008 - 02:05 PM
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MEMPHIS, -- U.S. medical scientists have identified the signaling system that halts the growth of medulloblastoma tumors -- a childhood brain cancer. Scientists at St. Jude Children's Research Hospital discovered proteins BMP2, BMP4 and BMP7 inhibit the growth of medulloblastoma tumors, while inducing malignant cells to develop into normal neurons. The researchers say their findings might lead to safer treatments for the rare, but often fatal, childhood brain tumor. "We think we have identified a pathway that can be used to prevent tumor formation and a potential target for therapy," said Martine Roussel of the St. Jude Department of Genetics and Tumor Cell Biology. A report on the work appears in the journal Genes & Development.
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Posted by: Little White Dove on Saturday, April 19, 2008 - 02:05 PM
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ST. LOUIS, -- U.S. scientists have discovered patients and caregivers experience relief, not anxiety or depression, when told of a diagnosis of Alzheimer's disease. Dr. John Morris and Professor Brian Carpenter of Washington University in St. Louis studied 90 individuals who came to the University's Alzheimer's Disease Research Center for an evaluation. Of those, 69 percent were diagnosed with Alzheimer's disease. Patients and caregivers were interviewed before and after the diagnosis. "The major finding is that both patients and their families feel relief, not increased anxiety, upon learning the diagnosis," said Morris, who noted anxiety among both patients and caregivers decreased substantially, and no significant changes in depression were noted. Carpenter said the study was conducted to generate data to convince physicians that most people don't become depressed, upset or suicidal. "So, this fear that (physicians) have about telling them and disturbing them is probably not legitimate for most people," added Carpenter. Although nobody wants to hear a diagnosis of Alzheimer's disease, Morris said at least having the diagnosis allows people to make plans for the future, including treatment as appropriate. The study appears in the Journal of the American Geriatrics Society.
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Posted by: Little White Dove on Sunday, April 13, 2008 - 02:05 PM
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CHICAGO, -- A U.S. research firm said the immune-system drug Gammagard may reduce the risk of contracting Alzheimer's disease. A study of medical claims data by Surveillance Data Inc. shows that patients treated with intravenous immunoglobulin, marketed as Gammagard by Baxter International, were less likely to develop Alzheimer's and related disorders, the Chicago Tribune said Thursday. The report looked at 847 patients who were treated with Gammagard and 84,700 who were not. Dementia was diagnosed in 2 percent of treated cases, compared with 4.2 percent for the untreated control group. The newspaper said researchers are looking at the possibility that Gammagard can clear the brain of a protein fragment known as beta-amyloid that is thought to be a key in the development and progression of Alzheimer's.
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Posted by: Little White Dove on Saturday, April 12, 2008 - 02:05 PM
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BERKELEY, Calif., -- U.S. scientists said researchers may soon be able to use brain-scanning instruments to read someone's mind. Dr. Jack Gallant, a neuroscientist at the University of California in Berkeley, said his team has figured out how to use functional magnetic resonance imaging (fMRI) to tell what someone is looking at based on brain activity. A report, published online in the journal Nature, said it is the first step to being able to see the contents of someone's visual experiences. "When the deck of cards, or photographs, has about 120 images, we can do better than 90 percent correct," Gallant said. He said the next step is to interpret what someone is seeing without having the subject select from known images. The research team said a device that can read out the brain's activity could be used to assess damage from strokes, the effect of drug treatments or to help diagnose conditions such as dementia.
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Posted by: Little White Dove on Friday, April 11, 2008 - 02:05 PM
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SEATTLE, -- Scientists in Seattle plan to pay people to catch malaria in order to test the safety and efficacy of new vaccines. The Seattle Biomedical Research Institute and the PATH Malaria Vaccine Initiative are collaborating to build a Human Challenge Center at SBRI to test new
interventions against the deadly malaria parasite. "This center will allow us to greatly increase our ability to evaluate whether a new vaccine formulation should advance to testing in clinical trials in malaria-endemic populations," Dr. Christian Loucq of MVI said Wednesday in a statement. The laboratory's Malaria Clinical Trials Center will be one of only a handful of facilities of its kind in the world. Volunteers inoculated with a malaria vaccine candidate will be deliberately infected with malaria through the bite of malaria-infected mosquitoes to assess whether or not the candidate vaccine can prevent or delay malaria infection. The Seattle Times said the strain of malaria used in the testing is a cloned strain that can be quickly cured. More than 900 people have participated in similar tests at Walter Reed Army Institute of Research. There are also labs in Britain and the Netherlands, the newspaper said.
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Posted by: Little White Dove on Thursday, April 10, 2008 - 02:05 PM
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ATLANTA, -- U.S. researchers have created a sensor necklace that someday may help people remember the last time they took their pills. The MagneTrace records the exact time and date when specially designed pills are swallowed and lets the user know if any doses are missed, Maysam Ghovanloo of the Georgia Institute of Technology said Wednesday in a news release. The necklace contains an array of magnetic sensors that can detect when pills containing a tiny magnet passes through a person's esophagus. The sensors also can be incorporated into a patch attached to the chest. "Forgetfulness is a huge problem, especially among the elderly, but so is taking the medication at the wrong time, stopping too early or taking the wrong dose," Ghovanloo said. "Studies show that drug noncompliance costs the country billions of dollars each year as a result of re-hospitalization, complications, disease progression and even death." The research
was published in the IEEE Sensors Journal.
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Posted by: Little White Dove on Wednesday, April 09, 2008 - 02:05 PM
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NEW YORK, -- A U.S. researcher suggests gastrointestinal by-pass operations may effectively cure Type 2 diabetes. Dr.-Francesco Rubino of New York-Presbyterian Hospital/Weill Cornell Medical Center said rerouting the gastrointestinal tract through gastric bypass can cause diabetes remission independent of any weight loss, even in subjects who are not obese., The findings are published in the journal Diabetes Care, the medical center said Wednesday in a news release. Rubino, chief of gastrointestinal metabolic surgery, said gastrointestinal bypass procedures control diabetes by by-passing the upper small intestine -- the duodenum and jejunum. "It should not surprise anyone that surgically altering the bowel's anatomy affects the mechanisms that regulate blood sugar levels, eventually influencing diabetes," Rubino said in a statement. He said the operation may work by reversing abnormalities of blood glucose regulation.
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Posted by: Little White Dove on Tuesday, April 08, 2008 - 02:05 PM
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WASHINGTON, -- Drug counterfeiters may have added an ingredient into Chinese shipments of Baxter's blood-thinner heparin, linked to 19 deaths, a U.S agency said. A foreign substance similar to heparin's chemical composition was found in as much as 25 percent of the material in the nine suspect lots of the drug, Dr. Janet Woodcock, acting director of the U.S. Food and Drug Administration's center for drug evaluation and research, said Wednesday. Conventional quality and safety testing performed by Baxter and its supplier, Scientific Protein Laboratories, didn't uncover any variation because the substance was similar to heparin, the Chicago Tribune reported. "It acts like heparin in this test, so it looks like everything is fine in the test," said Woodcock, who didn't reveal how the material was discovered. The contaminant was present in the active pharmaceutical ingredient originating from Scientific Protein's plant in China, the FDA said, adding it was possible the substance could have been added at the company's Waunakee, Wis., plant or at Baxter's Cherry Hill, N.J., processing facility. In a statement, Baxter said the cause "may be associated with the crude heparin, sources from China, or from subsequent processing of that product before it reaches Baxter."
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